Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 116-119.doi: 10.3969/j.issn.1673-8225.2011. 01.026

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Drug resistance and its mechanisms of cancer stem cells

Bao Qiu-ping, Li Hui-min   

  1. Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2010-09-05 Revised:2010-11-10 Online:2011-01-01 Published:2011-01-01
  • Contact: Li Hui-min, Master, Chief physician, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China lihuimin@medmail.com.cn
  • About author:Bao Qiu-ping★, Studying for master’s degree, Department of Hematology, First Affiliated Hospital, Kunming Medical College, Kunming 650032, Yunnan Province, China bqphapyst@163.com

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Abstract:

BACKGROUND: Tumor stem cells not only associate with multidrug resistance in cancer, and have a complex multi-drug resistance
OBJECTIVE: To review correlation of cancer stem cells to drug resistance and resistance mechanisms, and to provide new ideas for clinical therapy of tumor.
METHODS: We searched PubMed Western database and FMJS database (2003-2010) with the key words of “cancer stem cell, multiple drug resistance, apoptosis, cell cycle”. Wanfang database (2000-2010) and CNKI database (2000-2010) were searched by computer with the key words of “tumor, cancer stem cells, multidrug resistance”. A total of 56 Chinese literatures, 372 foreign languages literatures were collected. Published earlier, repeated and similar studies were excluded and 29 literatures were included.
RESULTS AND CONCLUSION: Stem cell research helps people deepen their knowledge of tumor occurrence, development and transfer. Tumor tissues have a small part of tumor cells that have self-renewal and unlimited proliferation ability as normal stem cells, but have a special mechanism of resistance. Tumor stem cells are closely related to tumor occurrence and treatment. However, complex multi-drug resistance of cancer stem cells requires further studies.

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